Eszopiclone

Description

Mechanism of Action
Lunesta (eszopiclone) works primarily by influencing GABA receptors in the brain, which play a role in promoting sleep and relaxation [2].

The drug remains active in the body for approximately 6 to 8 hours [1].

Lunesta is mainly broken down in the liver through two processes: oxidation and demethylation [1].

Pharmacokinetics
After oral intake, eszopiclone is rapidly absorbed through the gastrointestinal tract, typically within one hour [3].

It reaches its peak concentration in the bloodstream about an hour after administration and has a low affinity for binding to plasma proteins [4].

Lunesta and Anxiety
Research has explored Lunesta’s effects on individuals suffering from insomnia alongside generalized anxiety disorder (GAD) [7].

Participants aged 18 to 64, diagnosed with anxiety, were treated with both eszopiclone and escitalopram, an antidepressant with anti-anxiety properties.

Over a 10-week period, patients showed reduced Hamilton Anxiety Scale scores, along with improvements in sleep quality, daytime alertness, mood, and anxiety symptoms [7].

Dosage
Lunesta should only be taken under the guidance of a healthcare provider.

Generally, the initial dosage is between 1 to 2 mg at bedtime [2].

Some recommendations suggest beginning with 1 mg right before sleep. In older adults, doses should not exceed 2 mg [4].

Lunesta is available in tablet form at 1 mg, 2 mg, and 3 mg strengths. The total daily dose should not surpass 3 mg [4].

Each tablet contains the stated amount of eszopiclone along with inactive ingredients [4].

Drug Interactions
Lunesta can interact with other medications. For instance, it may have interactions with olanzapine, which is prescribed for conditions like schizophrenia, depression, and bipolar disorder [5].

Alcohol and other central nervous system depressants may also interact with Lunesta [3]. Additional interactions can occur with drugs such as rifampicin, an antibiotic [6].

Side Effects
Possible side effects of Lunesta include:

• Dizziness

• Dry mouth

• Coordination difficulties [8]

Many users also report a bitter taste in the mouth after taking the drug [3].

More serious side effects—such as hallucinations, memory issues, and mood changes—should be reported to a healthcare provider immediately [8].

Lunesta Withdrawal
Discontinuing Lunesta can lead to withdrawal symptoms due to physical and psychological dependence [9].

Symptoms may start as soon as 12 hours after the last dose, making it essential to consult a doctor before stopping use [9].

Common withdrawal effects include:

• Difficulty sleeping

• Anxiety

• Irritability

• Tremors

• Mood changes

• Panic attacks [9]

Important Considerations

• Never exceed the prescribed dosage of Lunesta.

• Only take it when you can get a full 7–8 hours of sleep.

• Use it right before going to bed.

• Speak to your doctor if insomnia doesn’t improve within 7–10 days [10].